New Publication: A Novel L-Alanine Dehydrogenase with Enhanced Bidirectional Catalysis

We are pleased to announce a new collaborative publication in the International Journal of Biological Macromolecules, in collaboration with Prof. Dr. Baris Binay’s research group at Gebze Technical University.

A novel Amycolatopsis sulphurea L-alanine dehydrogenase with enhanced bidirectional catalysis: Rational design, expression, and biochemical characterization

This study presents a rationally designed L-alanine dehydrogenase from Amycolatopsis sulphurea with enhanced bidirectional catalytic activity. Through computational protein engineering approaches combined with experimental validation, we successfully improved the enzyme’s performance for both forward and reverse reactions.

The work demonstrates the power of combining computational design with experimental biochemistry to optimize enzyme properties for potential biotechnological applications.

For more details, you can read the full paper here.